First report of cardiac tamponade in pediatric-onset mixed connective tissue disease

First report of cardiac tamponade in pediatric-onset mixed connective tissue disease

Mixed Connective Tissue Disease (MCTD) is relatively rare in children and typically presents with constitutional symptoms, rash, Raynaud’s phenomenon, and musculoskeletal symptoms. Cardiac involvement is an infrequent complication of MCTD usually occurring in the form of pericarditis without tamponade physiology. However, we present a case of a 10-year-old, previously healthy, African American ...

Massive Hemorrhagic Pericardial Effusion With Cardiac Tamponade as Initial Manifestation of Mixed Connective Tissue Disease

Mixed connective tissue disease (MCTD) is a distinct entity of connective tissue disorders characterized by overlapping clinical features of various autoimmune diseases along with the presence of antibodies to ribonucleoprotein (anti-RNP). The prevalence of cardiac involvement in MCTD varies from 13% to 65% and accounts for approximately 20% of MCTD related mortality. In this case, we describe ...

Exercise limitation in juvenile onset Mixed Connective Tissue Disease (MCTD)

Results VO2peak was significantly lower in patients with MCTD compared to the VO2peak of healthy subjects (z-score -1.9, p = 0.008). The strength of the proximal muscles (hip flexors, shoulder abductors, knee extensors) of the patients was significantly lower than the controls, whereas the strength of the distal muscles (dorsal flexors of the foot and grip strength) was rather similar. No clini...

Retinal Vasculitis and Choroidopathy in Pediatric-Onset Mixed Connective Tissue Disease

[Mixed connective tissue disease].

Mixed connective tissue disease deserves to be a distinct disease entity due to the persistent citation of this disease in the literature since the original description by Sharp in 1972, in spite of the presence of several criticisms against the independency of this disease. The characteristic features of mixed connective tissue disease are: 1) the presence of anti-U1snRNP antibody with high ti...